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Andre Villas-Boas' troops currently top the group with four points from two games while the Belgians have only a point to their name.
Genk arrive at Stamford Bridge with no form under their belt after losing three in a row and have failed to score in their opening two Champions League games against Valencia and Bayer Leverkusen.
The former Liverpool man could spearhead Chelsea's attack in place of Didier Drogba, although Nicolas Anelka will also be hoping to get the nod after being used off the bench at the weekend.
Villas-Boas is expected to ring the changes with Spain international Fernando Torres almost certain to start in the midst of his domestic three-match ban.
Several first-team stars are likely to be rested, possibly even captain John Terry and vice-captain Frank Lampard. Alex or David Luiz would be a like-for-like replacement at the back if Terry had the night off.
Chelsea vs Genk
"The most important thing for us is that we are aware of the amount of talent that we have at our disposal," said Villas-Boas, who will be without Ramires, with the midfielder rated 50-50 for Sunday's game at QPR.
"Any XI that we put across is a very, very strong XI. This puts us in a position of comfort to have always a good rest. There are situations that might happen regarding the QPR game."
Dutchman Mario Been's side are missing a number of key men for the daunting-looking the game in West London.
Forward Jelle Vossen, along with defensive trio Jose Nadson, Torben Jonelei and Jeroen Simaeys, is set to sit the game out through injury. Captain David Hubert is also unavailable.
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